Síntesis total del core de rac-tetrodotoxina: preparación de compuestos dioxadamantánicos

Tesis doctoral inédita, leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Química Orgánica. Fecha de lectura: 23/11/201

The Interaction of Biological and Environmental Factors in Predicting Educational Attainment: The Role of Early Pubertal Development Among Emerging Adult Women in Rural and Urban Settings

The inventlon provides highly functionahsed spiro-fused azetidinones having a cyclohexane moiety with the desired number of protected or unprotected hydroxyl groups or carbonated structures, which are introduced with high stereo and regioselectivity, as well as processes for their obtention.Peer reviewedA1 Solicitud de patente con informe sobre el estado de la técnic

A Study of Organization Communication towards Effective Decision Making -Roles of "Information" and Governance on IT Projects-

La invención proporciona intermedios útiles para la síntesis de TTX y análogos de la misma, así como procedimientos para la síntesis de los mismos. Los compuestos de la invención proporcionan acceso de forma flexible a distintos análogos de TTX.Peer reviewedConsejo Superior de Investigaciones CientíficasB1 Patente sin examen previ

Design of a biocatalytic cascade for the enzymatic sulfation of unsulfated chondroitin with in situ generation of PAPS

Sulfation of molecules in living organisms is a process that plays a key role in their functionality. In mammals, the sulfation of polysaccharides (glycosaminoglycans) that form the proteoglycans present in the extracellular matrix is particularly important. These polysaccharides, through their degree and sulfation pattern, are involved in a variety of biological events as signal modulators in communication processes between the cell and its environment. Because of this great biological importance, there is a growing interest in the development of efficient and sustainable sulfation processes, such as those based on the use of sulfotransferase enzymes. These enzymes have the disadvantage of being 3′-phosphoadenosine 5′-phosphosulfate (PAPS) dependent, which is expensive and difficult to obtain. In the present study, a modular multienzyme system was developed to allow the in situ synthesis of PAPS and its coupling to a chondroitin sulfation system. For this purpose, the bifunctional enzyme PAPS synthase 1 (PAPSS1) from Homo sapiens, which contains the ATP sulfurylase and APS kinase activities in a single protein, and the enzyme chondroitin 4-O-sulfotransferase (C4ST-1) from Rattus norvegicus were overexpressed in E. coli. The product formed after coupling of the PAPS generation system and the chondroitin sulfation module was analyzed by NMR

Regioselective functionalisation and protection of spirolactams

The invention provides highly functionalised spiro-fused lac tams of en formula (I) having a cyclohexane moiety With the desired number of protected or un-protected functional groups or carbonated structures, Which are introduced With high stereo and regioselectivity, as Well as processes for their obtention. These compounds are useful for the synthesis of abroad range of bioactive molecules, such as condoritols and aminoinositols and their analogues.Peer reviewedLaboratorios del Dr. Esteve S.A.A1 Solicitud de patente con informe sobre el estado de la técnic

N-benzyl-alpha-aminoamides comme inhibiteurs du complexe de promotion de l'anaphase/cyclosome (APC/C)

The invention relates to inhibitors of anaphase promoting complex/cyclosome (APC/C) function of formula I, wherein the meaning for R1 and R2 is as disclosed in the description. These compounds are useful in the treatment of cancer, particularly, in the treatment of breast cancer.NoConsejo Superior de Investigaciones Científicas (CSIC), Oxford Brookes UniversityA1 Solicitud de patente con informe sobre el estado de la técnic

Synthesis of ttx intermediates

The present invention relates to the synthesis of intermediates which are useful in TTX synthesis and to the preparation thereof.Peer reviewedA1 Solicitud de patente con informe sobre el estado de la técnic

Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications.The authors thank the Ministerio de Economía y Competitividad (grants MAT2015- 65184-C2-2-R and CTQ2016-79255-P) for their supportWe acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI

N-benzyl-alpha-aminoamides utilisés comme inhibiteurs du complexe de promotion de l'anaphase/cyclosome (APC/C))

[EN] The invention relates to inhibitors of anaphase promoting complex/cyclosome (APC/C) function of formula (I), wherein the meaning for R1 and R2 is as disclosed in the description. These compounds are useful in the treatment of cancer, particularly, in the treatment of breast cancer.[FR] L'invention concerne des inhibiteurs de la fonction du complexe de promotion de l'anaphase/cyclosome (APC/C) représentés par la formule (I), la signification de R1 et R2 étant telle que divulguée dans la description. Ces composés sont utiles dans le traitement du cancer, en particulier, dans le traitement du cancer du sein.NoConsejo Superior de Investigaciones Científicas (CSIC), Oxford Brookes UniversityA1 Solicitud de patente con informe sobre el estado de la técnic

Síntesis de intermedios de la ttx

[EN] The present invention relates to the synthesis of intermediates that can be used in TTX synthesis and to the preparation thereof.[ES] La presente invención se refiere a la síntesis de intermedios útiles en la sintesis de TTX, y a la preparación de los mismos.Peer reviewedConsejo Superior de Investigaciones Científicas (España)A1 Solicitud de patente con informe sobre el estado de la técnic